In those days, when your numbers have increased greatly in the land,” declares the LORD, “people will no longer say, ‘The ark of the covenant of the LORD.’ It will never enter their minds or be remembered; it will not be missed, nor will another one be made. Jeremiah 3:16 NIV

Bible prophecy seems to indicate that the lost Ark of the Covenant will make a return in the last days. Likely to be set up in a third Jewish temple when that temple is eventually built.